Geriatric Research Education and Clinical Center (GRECC)

Salt Lake City GRECC

• Blood pressure, blood flow, and metabolic regulation in both aging and disease
• Cellular mechanisms of vascular aging and atherosclerosis
• Neuroinflammation and brain metabolism with aging
• Decision support tools and collection of data for surveillance, analysis, and program evaluation

• Passive limb movement: a tool to assess vascular health and guide rehabilitation
• Targeting oxidative stress to prevent vascular and skeletal muscle dysfunction during disuse
• Efficacy of exercise training in patients with heart failure with preserved ejection fraction
• Novel approaches for improving vascular function in Veterans with heart failure with preserved ejection fraction
• Vascular endothelial function: a potential therapeutic target in Alzheimer’s disease
• Premature fatigue in patients with heart failure: neuronal influences
• Nicotine effects on host inflammation
• Mechanisms of augmented atherosclerotic progression with aging
• Amelioration of aged endothelial dysfunction by nampt and caloric restriction
• Telomere uncapping and arterial dysfunction
• Platelet reprogramming during inflammation
• The role of dacilzumab or disease through interaction with oligodendrocyte
• Pragmatic evaluation of events and benefits of lipid-lowering in older adults (PREVENTABLE) clinical trial site

• Interprofessional training in that cultivates future geriatrics leaders (Advanced Geriatrics Fellowship and T32 training programs)
• Regular host of the Rocky Mountain Geriatrics Conference for attendees nationwide on key geriatrics topics
• A resource locally and nationally for staff and associated health trainee continuing education

• Dementia telemedicine initiatives for Veterans and their caregivers, especially in the rural, Intermountain West
• Coordination of benefits with community agencies such as Area Agencies on Aging and home health agencies
• Improving access for highly rural Veterans
• Leveraging informatics data resources to inform geriatric clinical care
• Care Transitions from Hospital to SNF, including use of PharmD as well as RN led teams
• Improving care for older adult surgical patients through use of a Geriatric Surgery Interdisciplinary Team

• Reboussin DM, Gaussoin SA, Pajewski NM, Jaeger BC, Sachs B, Rapp SR, Supiano MA, Cleveland ML, Hunter V, Demons JL, Ogrocki PK, Lerner AJ, Chelune GJ, Wadley VG, Scales ML, Woolard NF, Perdue LH, Callahan KE, Williamson JD. Long-Term Effect of Intensive vs Standard Blood Pressure Control on Mild Cognitive Impairment and Probable Dementia in SPRINT. Neurology. 2025 Feb 11;104(3):e213334. doi: 10.1212/WNL.0000000000213334. Epub 2025 Jan 16. PMID: 39819096; PMCID: PMC11737843.
• Association of Intensive vs Standard Blood Pressure Control With Cerebral White Matter Lesions JAMA https://pubmed.ncbi.nlm.nih.gov/31408137/
• Strong Relationship Between Vascular Function in the Coronary and Brachial Arteries Hypertension https://pubmed.ncbi.nlm.nih.gov/31055952/
• Veterans Caregiving for Others: Caregiving as a Factor in the Health of America's Military Veterans Mil Med https://pubmed.ncbi.nlm.nih.gov/29901741/
• Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress J Mol Cell Cardiol https://pubmed.ncbi.nlm.nih.gov/30502348/
• Farrell TW, Hogans BB, Moo L, Jump R, Markland A, Alessi C, Barczi S, Bej T, Bonomo RA, Butler J, Eleazer GP, Flinton P, Rupper RW, Supiano MA, Shaughnessy M; GRECC Directors Association. Impact of Veterans Affairs Geriatric Research, Education, and Clinical Centers: Incubators of innovation in geriatrics. J Am Geriatr Soc. 2024 Nov;72(11):3315-3326. doi: 10.1111/jgs.19082. Epub 2024 Jul 31. PMID: 39082830.

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